Quantify pTau217, eMTBR, NfL, GFAP and other Neurodegenerative Disease Biomarkers With One Simple Workflow
Achieve ultrasensitive quantification with SPLASH™ kits, through a bench-ready workflow that turns sample into actionable data in under 3 hours.
The biomarkers critical to understanding neurodegenerative disease are still the hardest to measure.
Until now.
Biomarkers like pTau-217, NfL, GFAP, and Aβ42/40 are advancing how we understand neurodegeneration. But they’re only useful if your lab can actually measure them.
SPLASH (Solid Phase Ligation Assay with Single wasH) kits bring ultrasensitive protein biomarker quantitation directly to your bench, combining reliable analytical performance with a workflow any lab can adopt.
The AD 5-plex, validated on 101 samples
See how Taudia’s SPLASH AD 5-plex captures the full Alzheimer’s biomarker story, amyloid, tau, neuronal injury, and astrocytic activation, from a single drop of plasma.
What’s inside
- Proven precision across all five markers
- Strong prediction of amyloid PET positivity
- Performance benchmarked against leading assays
- The complete benchtop workflow, start to finish
Faster, Simpler, and In-House: The New Standard for Biomarker Detection
Ultrasensitive precision for low-abundance biomarkers
Validated performance across dynamic range, signal-to-background, and dilution linearity for biomarkers including pTau-217, Aβ42/40, NfL, and GFAP.
A 3-step workflow with less than 10 minutes of hands-on time
No specialized training or dedicated instrumentation required, just your existing qPCR instrument and standard lab consumables.
Reliable quantitation across every run
100% quantifiability from just a few µL of sample, with performance validated against leading ultrasensitive platforms.
Engineered to scale as your research evolves, without adding complexity.
SPLASH kits maintain one consistent 3-step protocol across every plex level. Flexible configurations support each stage of your program, from single-analyte validation to a full Alzheimer’s disease panel, with the same reliable workflow throughout.
Duplex
Run paired biomarkers for ratio calculations like Aβ42/40 or capture complementary markers of tau pathology and neuroinflammation simultaneously.
Five Plex
Quantify pTau-217, Aβ42, Aβ40, NfL, and GFAP together in a single reaction for comprehensive Alzheimer’s disease biomarker profiling. Designed for studies that require a complete picture of amyloid pathology, tau phosphorylation, neuronal injury, and astrocytic activation.
Single-well multiplexing: Quantify multiple proteins from the same sample without sacrificing performance.
A Novel Dried Plasma Spot (DPS)-Based Workflow for Quantification of Alzheimer's Disease Diagnostic Biomarkers
FAQ
Can the same biomarker platform be used for different neurodegenerative diseases and sample types?
Yes. SPLASH™ kits are designed for ultrasensitive protein biomarker quantitation across multiple neurodegenerative disease applications. The same core workflow supports quantification of biomarkers relevant to Alzheimer’s disease, Parkinson’s disease, and other neurological conditions. SPLASH™ kits have been validated in plasma and cerebrospinal fluid (CSF), and Taudia is actively expanding compatibility to additional sample matrices, including dried plasma spots (DPS).
Which qPCR instruments are compatible with SPLASH™ kits?
SPLASH™ kits are compatible with standard qPCR instruments in a 96-well format. Because the assay uses conventional fluorescence-based qPCR readout, most commonly available qPCR systems can be used without modification. The number of targets that can be multiplexed in a single well depends on the fluorescence channels available on your specific instrument.
How do SPLASH™ singleplex and multiplex kits compare in performance?
SPLASH™ kits are engineered to maintain consistent analytical performance across singleplex, duplex, and 5-plex configurations. Labs can scale from single-analyte studies to comprehensive biomarker panels without sacrificing data quality.
Do SPLASH™ kits include calibration standards for biomarker quantitation?
Yes. SPLASH™ kits include calibration standards that enable absolute quantitation in pg/mL. These standards are developed to support accurate, reproducible biomarker measurement across different laboratories and qPCR instruments.
Are SPLASH™ kits validated for lot-to-lot consistency?
Yes. Lot-to-lot consistency is a core part of Taudia’s quality process.
Ready to bring ultrasensitive biomarker detection to your bench?
Let’s match you with the right kit for your program.