Quantify Low-Abundance Neurodegenerative Disease Biomarkers With One Simple Workflow
Achieve ultrasensitive quantification with SPLASH™ kits, through a bench-ready workflow that turns sample into actionable data in under 3 hours.
The biomarkers critical to understanding disease are still the hardest to measure.
Until now.
Biomarkers like pTau-217, NfL, GFAP, and Aβ42/40 are advancing how we understand neurodegeneration. But they’re only useful if your lab can actually measure them.
SPLASH (Solid Phase Ligation Assay with Single wasH) kits bring ultrasensitive protein biomarker quantitation directly to your bench, combining reliable analytical performance with a workflow any lab can adopt.
Faster, Simpler, and In-House: The New Standard for Biomarker Detection
Ultrasensitive precision for low-abundance biomarkers
Validated performance across dynamic range, signal-to-background, and dilution linearity for biomarkers including pTau-217, Aβ42/40, NfL, and GFAP.
A 3-step workflow with less than 10 minutes of hands-on time
No specialized training or dedicated instrumentation required, just your existing qPCR instrument and standard lab consumables.
Reliable quantitation across every run
100% quantifiability from just a few µL of sample, with performance validated against leading ultrasensitive platforms.
Engineered to scale as your research evolves, without adding complexity.
SPLASH kits maintain one consistent 3-step protocol across every plex level. Flexible configurations support each stage of your program, from single-analyte validation to a full Alzheimer’s disease panel, with the same reliable workflow throughout.
Singleplex
Ideal for focused studies, method validation, clinical trial screening, or labs adding a specific analyte to an existing workflow.
SPLASH kit:
Brain Derived pTau-217
Duplex
Run paired biomarkers for ratio calculations like Aβ42/40 or capture complementary markers of tau pathology and neuroinflammation simultaneously.
Five Plex
Quantify pTau-217, Aβ42, Aβ40, NfL, and GFAP together in a single reaction for comprehensive Alzheimer’s disease biomarker profiling. Designed for studies that require a complete picture of amyloid pathology, tau phosphorylation, neuronal injury, and astrocytic activation.
SPLASH kit:
pTau-217, Aβ42, Aβ40, NfL, GFAP
Single-well multiplexing: Quantify multiple proteins from the same sample without sacrificing performance.
A Novel Dried Plasma Spot (DPS)-Based Workflow for Quantification of Alzheimer's Disease Diagnostic Biomarkers
Ready to bring ultrasensitive biomarker detection to your bench?
Let’s match you with the right kit for your program.